CISSE 2010 provides a virtual forum for presentation and discussion of the state-of the-art research on computers, information and systems sciences and engineering. CISSE 2010 is the sixth conference of the CISSE series of e-conferences. CISSE is the World's first Engineering/Computing and Systems Research E-Conference. CISSE 2005 was the first high-caliber Research Conference in the world to be completely conducted online in real-time via the internet. In 2005, CISSE received 255 research paper submissions and the final program included 140 accepted papers, from more than 45 countries. Last year, CISSE 2009 received more than 500 submissions and the final program included 210 accepted papers, from more than 80 countries. The virtual conference will be conducted through the Internet using web-conferencing tools, made available by the conference. Authors will be presenting their PowerPoint, audio or video presentations using web-conferencing tools without the need for travel. Conference sessions will be broadcast to all the conference participants, where session participants can interact with the presenter during the presentation and/or during the Q&A slot that follows the presentation. This international conference will be held entirely on-line. The accepted and presented papers will be made available and sent to the authors after the conference both on a DVD (including all papers, PowerPoint presentations and audiopresentations) and as a book publication. Springer, the official publisher for CISSE, published the 2009 proceedings in 2 books. Conference participants - authors, presenters and attendees - only need an internet connection and sound available on their computers in order to be able to contribute and participate in this international ground-breaking conference. The on-line structure of this high-quality event will allow academic professionals and industry participants to contribute their work and attend world-class technical presentations based on rigorously refereed submissions, live, without the need for investing significant travel funds or time out of the office. The concept and format of CISSE is ground-breaking. The PowerPoint presentations, final paper manuscripts and time schedule for live presentations over the web had been available for weeks prior to the start of the conference for all registrants, so that the participants can choose the presentations they want to attend and think about questions that they might want to ask. The live audio presentations were also recorded and are part of the permanent CISSE on-line archive - accessible to all registrants- which also includes all the papers, PowerPoint and audio presentations. Potential non-author conference attendees who cannot make the on-line conference dates are encouraged to register, as the entire joint conferences will be archived for future viewing. The CISSE conference audio room provides superb audio even over low speed internet connections, the ability to display PowerPoint presentations, and cross-platform compatibility (the conferencing software runs on Windows, Mac, and any other operating system that supports Java). In addition, the conferencing system allowed for an unlimited number of participants, which in turn granted us the opportunity to allow all CISSE participants to attend all presentations, as opposed to limiting the number of available seats for each session.